Charlton R, et al. - The risk of uveitis and inflammatory bowel disease (IBD) in patients with psoriatic arthritis (PsA) compared with the general population and patients with psoriasis was ascertained in this study. In a primary care-based incidence cohort of patients with PsA, there were substantial risks of developing uveitis and/or Crohn's disease, but not ulcerative colitis, when compared with the general population and psoriasis controls.

Methods

• Between 1998 and 2014, they utilizing information from the UK Clinical Practice Research Datalink for this study.
• Patients with incident PsA aged 18-89 years were identified and matched to a cohort of patients with psoriasis and a general population cohort.
• The incidence of uveitis, all IBD, Crohn’s disease and ulcerative colitis was calculated for each study cohort and adjusted relative risks (RRadj) were ascertained utilizing conditional Poisson regression.

Results

• They identified total 6783 incident cases of PsA.
• In this study, the median age was 49 years.
• The current study showed that the risk of uveitis was significantly higher in the PsA cohort than in the general population and psoriasis cohorts (RR_adj3.55, 95% CI 2.21 to 5.70 and RR_adj 2.13, 95% CI 1.40 to 3.24, respectively).
• A significant increase was observed for Crohn’s disease (RR_adj 2.96, 95% CI 1.46 to 6.00 and RR_adj3.60, 95% CI 1.83 to 7.10) but not for ulcerative colitis (RR_adj1.30, 95% CI 0.66 to 2.56 and RR_adj0.98, 95% CI 0.50 to 1.92).