Guitton Z, et al. - Experts assessed the effectiveness and safety of thrombopoietin-receptor agonists (TPO-RAs) in systemic lupus erythematosus (SLE)-assofciated ITP. Participating centres included secondary- or tertiary-care hospitals belonging to the French national network for adult ITP. It was noted that 94% achieved response with TPO-RAs overall. Findings suggested systematical screening of aPLs before TPO-RA initiation in patients with SLE. Alternative therapy with aPL positivity (if possible) ought to be discussed, especially in patients with definite APS or suboptimal adherence to anti-coagulation therapy.