Risk of pneumonia associated with atypical antipsychotic use in nursing home residents with Parkinson disease
Journal of Psychiatric Research Aug 01, 2019
Chekani F, et al. - In elderly nursing home residents with Parkinson disease (PD), researcher assessed how the risk of pneumonia is related to inappropriate atypical antipsychotic (AAP) use. Older adults (aged 65 years or older; n = 12,076) with a diagnosis of PD and with comorbid depression who began AAP medication were studied. They defined/listed aripiprazole, clozapine or quetiapine according to 2015 Beers criteria as appropriate AAPs, and olanzapine, asenapine, brexpiprazole, iloperidone, lurasidone, paliperidone, risperidone, or ziprasidone as inappropriate AAPs. Patients with PD who used inappropriate AAP were at significantly higher risk of pneumonia vs appropriate AAP group in all analyses. In sensitivity analyses, they observed the pneumonia risk of 1.28 (1.12–1.47) for risperidone vs quetiapine and of 1.29 for olanzapine vs quetiapine.
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