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Risk of neuropsychiatric diseases according to the use of a leukotriene receptor antagonist in middle-aged and older adults with asthma: A nationwide population-based study using health claims data in Korea

The Journal of Allergy and Clinical Immunology: In Practice Jun 24, 2021

Shim JS, Kim MH, Kim MH, et al. - In view of the increasing concern regarding neuropsychiatric (NP) adverse reactions linked with using leukotriene receptor antagonist (LTRA), an effective drug for asthma, researchers herein sought for evidence concerning this association in adults with asthma. They used data from the National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) for performing this nationwide, retrospective, cohort study. Overall, they enrolled 61,571 asthma patients without LTRA experience, 12,168 of whom took LTRA during the follow-up period. Analysis yielded no evidence supporting the association between the use of LTRA and the occurrence of NP diseases in Korean adult asthmatics aged 40 or older.

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