Salomon LJ, et al. - Researchers conducted a systematic review of the literature and an updated meta-analysis in order to assess the procedure-related risk of miscarriage after amniocentesis and chorionic villus sampling (CVS). Searching MEDLINE, EMBASE and The Cochrane Library, they selected 12 controlled studies for amniocentesis and seven for CVS for this systematic review. Following 63,723 amniocentesis procedures, 580 miscarriages were reported, resulting in a weighted risk of pregnancy loss of 0.91%. They identified 1,726 miscarriages in 330,469 pregnancies with a loss rate of 0.58% in the control group. Findings suggest a negligible procedure-related risk of miscarriage after CVS and amniocentesis, particularly when such risks are compared between invasive-procedure and control groups with a similar background-risk profile for chromosomal abnormalities. Further, they identified no evidence that CVS is less safe than amniocentesis.