Littman AJ, Tseng CL, Timmons A, et al. - Researchers investigated whether a change has occurred over time in the risk of subsequent lower-limb amputations and death following an initial toe amputation among individuals with diabetes. In addition, they determined if this risk varies by demographic characteristics and geographic region. From October 1, 2004 to September 30, 2016, Veterans health administration electronic medical records yielded data of 17,786 individuals who had an initial toe amputation. Among these, another amputation on the same limb was reported in 34% within 1 year, including 10% who had a major ipsilateral amputation. Reamputation is thus required in nearly one-third of individuals following an initial toe amputation, although there is a decrease in the risks of subsequent major ipsilateral amputation over time. Nevertheless, African Americans particularly exhibit high risks and the risks vary substantially geographically.