Kim WJ, Lee SJ, Lee E, et al. - Factors linked with incident dementia included mild degrees of hyperglycemia and presence of comorbidities. Intervention during the prodromal stage of a chronic disease (e.g., prediabetes) could be given consideration in order to prevent dementia development.

• This study utilized a health insurance claims database and the results of biennial health examinations in South Korea, to include 8,400,950 persons aged ≥40 years followed until 2016, divided as normoglycemia, impaired fasting glucose (IFG), new-onset diabetes, or known diabetes.

• All-cause dementia occurred in 4.2% (n=353,392) of participants during the observation span of 48,323,729 person-years.

• Relative to normoglycemia, adjusted hazard ratios in IFG, new-onset diabetes, known diabetes <5 years, and in known diabetes ≥5 years were 1.01, 1.45, 1.32, and 1.62, respectively.

• Presence of diabetes impacted the links between ischemic heart disease and chronic kidney disease with incident dementia.

• There appeared a greater relationship of ischemic stroke, vs diabetes, with incident dementia.