Hefler L, et al. - In a prospective register study, researchers evaluated a total of 1024 women with thickened endometrium in ultrasound examination undergoing histological diagnosis by dilation, hysteroscopy and curettage, for the risk of endometrial cancer (EC). The univariate analysis revealed a statistically significant correlation between endometrial thickness, current use of antihypertensive medication, number of deliveries, and the presence of endometrial fluid in preoperative vaginal ultrasound with EC. A multivariate logistic regression model incorporating these parameters revealed a statistically significant independent association of endometrial thickness, number of deliveries, and the presence of endometrial fluid in preoperative vaginal ultrasound, but not current use of antihypertensive medication, with EC. The data suggested a clinically reasonable cut-off of > 11 mm endometrial thickness to discriminate between “normal” and “pathological”