Arrieta O, Salas AA, Cardona AF, et al. - In locally advanced and metastatic (stages IIIB-IV) lung adenocarcinoma (LADC), researchers intended to determine if there is an association between the predominant histological subtype and the risk of developing brain metastases (BM). In total, 710 patients with LADC were treated at the institution from January 2010 to December 2017. After eliminating patients with brain metastases at diagnosis (n = 151), they were classified by International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) LAzDC classification to estimate the risk of developing brain metastases. An increased risk of developing BM was seen with the predominantly solid pattern (according to IASLC/ATS/ERS classification) in patients with locally advanced and metastatic LADC. Its prognostic value may help to explore innovative therapeutic methods, change earlier identification surveillance, avoid complications, and decrease morbidity.