Lee JS, Myung J, Lee HA, et al. - The results showed that in comparison with the general population, patients aged 41–55 years with gout have a higher risk of cancer and all-cause and cancer mortality. Thus, special attention should be paid to higher cancer risk and mortality in these individuals who are diagnosed in middle age.

• In this study, 4,176 patients with gout compared with 8,352 controls. In both groups, the mean age and follow-up duration were 48.8 years and 10.1 years.

• According to the findings, overall cancer risk was significantly different between gout patients and controls (HR 1.224, 95% CI 1.073–1.398).

• In patients with gout, the all-cause mortality (HR 1.457, 95% CI 1.149–1.847) and cancer mortality (HR 1.470, 95% CI 1.020–2.136) were higher.

• Subgroup analysis demonstrated that in patients with gout, the cancer risks of the stomach (HR 1.710, 95% CI 1.221–2.395), head and neck (HR 1.850, 95% CI 1.071–3.196), and hematologic or lymphoid organ (HR 2.849, 95% CI 1.035–7.844) were higher.