Coghill AE, et al. - Researchers used data from the HIV/AIDS Cancer Match Study (1996-2012) to determine incident breast, prostate, and colorectal cancer in people living with HIV or AIDS (PLWHA) vs general population cancer rates. For this purpose, they used standardized incidence ratios, overall and stratified by tumor stage/size, breast cancer estrogen receptor status, and colorectal site. On inverse standardized incidence ratios, the potential impact of study design and unmeasured confounding was also assessed. They found that PLWHA had markedly lower rates of breast, prostate, and colorectal cancer, including rates of distant-stage/large tumors that are not generally screen-detected. They noted that differential screening was unlikely to account for this set of inverse HIV-cancer associations. Instead, these associations may represent biological relationships.