Huang W, et al. - In order to assess the influence of the history of central nervous system (CNS) tumor on pregnancy outcome, researchers examined if children of CNS tumor survivors are at increased risk of being born preterm. They linked several nationwide registers in Sweden and identified 1,369 children whose parents were childhood or adolescent CNS tumor survivors. They randomly matched these children with children whose parents did not have a CNS tumor to generate the reference group. The prevalence of preterm birth (PTB) among children of survivors with CNS tumor vs the matched controls was 6.9% and 5.2% respectively. Compared with the matched controls, children of survivors had an increased risk of PTB. The risk was somewhat lower among the second child as compared with the first child for families with more than one child. They observed a negative correlation of risk with the time interval between parental diagnosis and childbirth. Offspring of those diagnosed in childhood but not adolescence specifically exhibited this increased risk. The highest risk of PTB was evident among offspring of childhood CNS tumor survivors and medulloblastoma or ependymoma survivors.