Rajpurkar M, et al. - Given that acute promyelocytic leukemia (APL) is characterized by an increased risk of coagulopathy with significant morbidity and mortality, researchers reported the evaluation of presenting white blood cell (WBC) and the International Society on Thrombosis and Haemostasis (ISTH) disseminated intravascular coagulation (DIC) scoring system as markers for early death and nonlethal coagulopathy in pediatric APL. For this investigation, 79 pediatric patients treated on a Children’s Oncology Group phase III clinical trial were evaluated. Findings suggested a significant association of elevated presenting WBC with early death but not with both lethal and nonlethal coagulopathy events. An ISTH DIC score of ≥5 was not correlated with either early deaths or coagulopathy events. However, an ISTH DIC score threshold of 6 was significantly related to early death and with both lethal and nonlethal coagulopathy events. The presenting WBC is a marker for risk of early death in pediatric APL patients. Other biomarkers that can predict APL-related coagulopathy need to be identified strongly.