Li X, Li L, Liu L, et al. - Researchers evaluated risk factors between multidrug resistant (MDR) pathogen and potential covariates in severe acute pancreatitis (SAP) patients in a retrospective analysis undertaken to evaluate MDR pathogen in SAP patients who were managed applying the step-up approach. They retrospectively gathered clinical data of 51 SAP patients who were managed from June 2013 to December 2016. This analysis included 23 patients in the MDR group and 28 in the non-MDR group. The leading cause of SAP was hyperlipidemia. Patients with MDR pathogen infections had a significantly longer mean duration of hospital stay. Much higher hospitalization expenses were reported in the MDR group vs non-MDR group. The MDR group vs non-MDR group experienced higher mortality. In SAP, potential risk factors for MDR pathogen-induced infections were: systemic disease, initial use of carbapenem, and open necrosectomy. Findings revealed that SAP patients commonly developed MDR pathogen-induced infections. The main pathogen was Acinetobacter baumannii. The independent risk factor identified for the infection of MDR pathogen was open necrosectomy.