Hamilton ZA, Capitanio U, Pruthi D, et al. - This study was attempted to assess risk factors for and outcomes in pathological T3a-upstaging in Renal Cell Carcinoma (RCC), as Tumor-Node-Metastasis staging for T3a RCC was recently revised. Researchers conducted a multicenter retrospective analysis including a total of 2573 individuals (1,223 RN/1350 PN) with clinical T1-T2 RCC, stratified by the occurrence of pathologic T3a-upstaging. The recurrence-free survival (RFS) was the primary endpoint. They applied Kaplan-Meier analysis (KMA) for RFS and overall survival (OS). The evidence showed that the risk of pT3a-upstaging and recurrence in pT3a-upstaged RCC associated with the clinical stage at presentation. It was noted that renal vein and perinephric fat invasion were correlated with an enhanced risk of recurrence. The results displayed that PN did not raise the risk of recurrence and the potential of pT3a-upstaging should not deter consideration of PN.