Fischer M, et al. - This study was performed to determine the proportion of patients developing disease flare requiring rescue therapy. In addition, the authors aimed to examine the risk factors correlated with disease flare after de-escalation of an immunomodulator (IM) from combination therapy. Following IM withdrawal, a large proportion of Crohn’s disease (CD) patients on combination therapy experienced a flare. Independent predictors of the need for rescue therapy were the young age at diagnosis, short duration of combination therapy, and methotrexate use.