Manodoro S, et al. – Here, researchers recognize risk factors for recurrence in a large series of patients with pelvic organ prolapse (POP) treated with primary transvaginal native–tissue repair involving high uterosacral ligament suspension. This study affirmed preoperative stage 3 or higher as a risk factor for prolapse recurrence. The study also recognized additional risk factors for surgical failure including lack of posterior repair, severe macrosomia, premenopausal status and obesity.

Methods

• For this research, they designed a retrospective study.
• Postoperative descent of POP–Q stage 2 or higher in any compartment was considered as recurrence.
• Global recurrence (GR) was characterized as any recurrence in any compartment irrespective of the surgical procedures performed amid primary prolapse surgery.
• True recurrence (TR) was characterized as recurrence in a compartment repaired amid primary prolapse surgery.

Results

• Of a total of 533 eligible women, 519 were available for follow–up.
• Univariate investigation demonstrated that age ≤50 years, premenopausal status, obesity (BMI >30 kg/m²), history of severe macrosomia (>4,500 g), preoperative POP stage 3 or higher and absence of anterior repair at the time of POP surgery were risk factors for GR.
• Multivariate investigation affirmed lack of posterior repair (odds ratio, OR, 1.8), severe macrosomia (OR 2.7), premenopausal status (OR 3.9), obesity (OR 2.2) and preoperative stage 3 or higher (OR 2.6) as risk factors for GR.
• Univariate investigation demonstrated that premenopausal status and preoperative POP stage 3 or higher were risk factors for TR.
• Multivariate investigation affirmed premenopausal status (OR 4.0) and preoperative stage 3 or higher (OR 4.5) as risk factors for TR.