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Risk factors for posttreatment recurrence in patients with intermediate-risk papillary thyroid carcinoma

American Journal of Surgery Feb 07, 2020

Kim Y, Roh JL, Song DE, et al. - Researchers examined 1,782 patients who underwent thyroidectomy for intermediate-risk papillary thyroid carcinoma in order to determine the risk factors for posttreatment recurrence in these patients. In univariate analyses, clinical and pathological cervical lymph node positivity (cN1 and pN1), aggressive histology, and multifocality with microscopic extrathyroidal extension were noted to be significantly correlated with RFS outcomes. In multivariate analyses, the independent factors predictive of RFS were cN1, > 5 pN1, and posttreatment radioactive iodine-avid metastatic foci in the ATA intermediate-risk category. There appeared an increase in the posttreatment recurrence rate in correlation to the combination of any three or more of these intermediate-risk factors.
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