Tomari S, et al. - Researchers carried out this study to identify the predictors of seizure recurrence in patients with the first episode of post-stroke seizure. Status epilepticus and younger age were the predictors of recurrence after the early and late seizure, respectively, in patients with post-stroke seizure.

• Between July 2010 and June 2014, the researchers retrospectively identified patients admitted to their hospital because of the first episode of post-stroke seizure and followed-up until June 2015.
• Post-stroke seizure was classified as early (within 1 week after stroke) or late (in the second week or later).
• The baseline clinical characteristics and treatment between the groups were compared.
• They investigated the factors that determined seizure recurrence by Cox proportional hazards model.

• The researchers enrolled 153 patients (84 men; mean age, 73.7 ± 12.3 years; 73 hemorrhagic and 80 ischemic strokes; 63 early and 90 late seizure).
• The early seizure group more frequently manifested with status epilepticus compared with the late seizure group,; tended to less often undergo stereotactic aspiration of hematoma,; and less frequently used anti-epileptic drugs.
• 40 patients were lost to follow-up during the observation period (median 364 days, IQR 124-680 days).
• Subsequently, 113 patients were included in the analysis.
• Compared to the late seizure group, the early seizure group had lower survival and seizure recurrence rates.
• The presence of status epilepticus in the early group (HR 4.75, 95% CI 1.28–17.62) and younger age in the late seizure group (HR 0.95, 95% CI 0.93–0.99) were the factors significantly associated with seizure recurrence.