Dikilitas O, et al. - Researchers investigated the factors that confer risk for polyvascular involvement in patients experiencing peripheral artery disease (PAD). They used an inverse‐variance‐weighted approach to conduct 2‐sample Mendelian randomization, to evaluate 60 exposures including size and lipid content of atherogenic lipoproteins, blood pressure, glycated hemoglobin, as well as smoking as causal mediators for polyvascular disease in PAD cases. This study involved 3,279 patients with PAD, among those, polyvascular disease was present in 61%. The following factors were related to polyvascular involvement in patients with PAD: lifetime exposure to increased lipid content and concentrations of very small and small very low‐density lipoprotein, intermediate‐density lipoprotein, and large low‐density lipoprotein particles as well as increased blood pressure. Progression of atherosclerosis in patients with PAD may be limited via decrease in levels of such exposures.