Hames DL, et al. - Researchers undertook this single-center, retrospective cohort analysis to determine the factors that confer risk for mortality in critically ill children needing renal replacement therapy. This inquiry was performed on all patients admitted to an ICU at Boston Children’s Hospital from January 2009 to December 2017 who needed any form of renal replacement therapy. Findings revealed that lower mortality was observed in this cohort of critically ill children in relation to earlier renal replacement therapy start with respect to the development of severe acute kidney injury. In addition, increased mortality was observed in relation to invasive mechanical ventilation at the time of renal replacement therapy start and a higher degree of fluid accumulation following the commencement of renal replacement therapy.