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Risk factors for mortality and circulatory outcome among neonates prenatally diagnosed with Ebstein anomaly or tricuspid valve dysplasia: A multicenter study

Journal of the American Heart Association Nov 11, 2020

Freud LR, McElhinney DB, Kalish BT, et al. - Researchers sought to describe the management strategies of this large, multicenter cohort of prenatally diagnosed neonates with severe Ebstein anomaly or tricuspid valve dysplasia (EA/TVD), as well as to define clinical and echocardiographic factors associated with neonatal mortality and, among survivors, a palliated vs biventricular circulatory outcome at the time of discharge. This 23‐center, retrospective study from 2005 to 2011 involved 243 fetuses with EA/TVD. A variety of management strategies were used across centers, with poor outcomes overall, among neonates with EA/TVD diagnosed in utero. Findings suggested that high‐risk patients with low tricuspid regurgitation jet velocity and no antegrade pulmonary blood flow should be considered for right ventricular exclusion in order to optimize their chance of survival.

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