Risk factors for mortality and circulatory outcome among neonates prenatally diagnosed with Ebstein anomaly or tricuspid valve dysplasia: A multicenter study
Journal of the American Heart Association Oct 31, 2020
Freud LR, McElhinney DB, Kalish BT, et al. - Researchers sought to describe the management strategies of this large, multicenter cohort of prenatally diagnosed neonates with severe Ebstein anomaly or tricuspid valve dysplasia. Furthermore, clinical and echocardiographic factors associated with neonatal mortality and a palliated vs biventricular circulatory outcome at discharge among survivors were also sought to be identified. Two hundred forty-three fetuses with Ebstein anomaly or tricuspid valve dysplasia were included in this 23‐center, retrospective study from 2005 to 2011. Among live‐born patients, clinical and echocardiographic factors were assessed for correlation with neonatal mortality and palliated versus biventricular circulation at discharge. A variety of management strategies were used across centers, with poor outcomes overall, among neonates with Ebstein anomaly or tricuspid valve dysplasia diagnosed in utero. In order to maximise the probability of survival, high-risk patients with low tricuspid regurgitation jet velocity and no antegrade pulmonary blood flow should be considered for right ventricular exclusion.
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