Boatman JA, et al. - Researchers sought risk factors for low CD4⁺ recovery despite viral suppression among HIV-positive individuals initiating treatment at CD4⁺ counts of >500 cells/mm³ in the Strategic Timing of AntiRetroviral Therapy trial. They defined low CD4⁺ recovery as a CD4⁺ increase of <50 cells/mm³ from baseline after 8 months despite viral load of ≤200 copies/mL. As per outcomes, participants starting antiretroviral therapy (ART) at high CD4⁺counts frequently display low CD4⁺ recovery. Male sex, lower screening CD4⁺ cell counts, higher CD8⁺ cell counts, and lower HIV RNA levels were the risk factors for low CD4⁺ recovery.