Valachis A, et al. - Potential risk factors for local disease recurrence (LR) and locoregional disease recurrence (LRR) after neoadjuvant chemotherapy (NCT) and breast-conserving therapy (BCT) were determined by pooling individual patient data sets from 9 studies and using a 1-stage meta-analytic approach as well as Cox proportional hazards regression models. The observed 10-year LR rate was 6.5%, whereas the 10-year LRR rate was 10.3%. The factors that showed relation to a higher risk of LR included estrogen receptor-negative disease, cN + disease, a lack of pathologic complete response in axilla (pN0), and pN2 to pN3 disease. Overall, for a large percentage of patients with breast cancer, BCT after NCT was shown to be an oncologically safe procedure. Moreover, in order to provide assistance to clinicians in regards to detection of patients at higher risk of LR and LRR after NCT and BCT and individualize the postoperative treatment plan and follow-up, two easy-to-use clinical scores were developed.