Risk factors for increased serum creatinine level in patients with psoriasis treated with cyclosporine in a real-world practice
Dermatologic Therapy Mar 23, 2019
Hong JR, et al. - A sum of 611 individuals were assessed to examine the consequences of intermittent cyclosporine therapy on nephrotoxicity risk among subjects with psoriasis, between January 2013 and January 2017. They observed that 4.5% of cases exhibited a more than 25% increase in serum creatinine levels. They found age over 60 years, diabetes, and obesity, the significant risk factors of increased serum creatinine levels in psoriasis cases. No significant relation of the treatment duration or cumulative dose of cyclosporine with increased serum creatinine levels was noted. Hence, they suggested intermittent cyclosporine use with regular serum creatinine tests to treat psoriasis.
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