de Sousa LFA, et al. - Forty-nine female with Juvenile-onset systemic lupus erythematosus (JoSLE) patients were assessed at baseline and following a 3.5-year follow-up regarding clinical, laboratory, areal bone mineral density and bone microarchitecture parameters using high-resolution peripheral quantitative computed tomography (HR-pQCT) by the researchers in order to analyze the risk factors for bone mass loss in JoSLE patients. A greater frequency of alcohol intake, inadequate calcium consumption and lower levels of baseline procollagen type 1 amino-terminal propeptide (P1NP) in the aBMD loss (BL) group was noted. Furthermore, in the BL group, worsening of HR-pQCT parameters trabecular volumetric density and cortical thickness was seen. Moreover, a higher frequency of renal activity was noted on contrasting the BL + no change with the aBMD gain group. This was the first longitudinal study to assess the risk factors of bone loss in JoSLE patients. The significance of assessing lifestyle habits and renal disease activity in these young women was burdened on. Moreover, trabecular and cortical compartments deteriorated, and low levels of amino-terminal propeptide could be a prognosticator of bone impairment in JoSLE.