Burton BN, et al. - Because otogenic brain abscess is a well-recognized clinical condition describing secondary brain abscess to an ear infection or mastoiditis, researchers reported the mortality rate among patients who did and did not receive mastoidectomy and identified factors correlated with inpatient mortality. For years 2008 to 2014, a cohort of patients who in their inpatient hospitalization carried the diagnoses of both brain abscess and infectious ear disease were identified in this retrospective cohort study. To identify the factors associated with inpatient mortality, a multivariable logistics regression model was developed. The final analysis involved 252 patients, 84 of whom were subject to mastoidectomy. Inpatient morbidity and mortality rates were 17.5% and 4.0%. The mortality rate was 4.2% vs 3.6% in patients without mastoidectomy vs those with mastoidectomy. Findings suggested an association of older age and Black race with increased odds of inpatient mortality and no significant differences were found in mortality between mastoidectomy cohorts. This research serves to generate additional hypotheses to investigate the association between sociodemographic factors and surgical variables with outcomes in this surgical population for larger observational studies.