Valderrama-Beltrán S, Gualtero S, Álvarez-Moreno C, et al. - Researchers conducted a multicenter cohort study with a nested case-control design in order to appraise the risk factors correlated with methicillin-resistant Staphylococcus aureus (MRSA) soft tissue infections (SSTIs) in Colombia. To evaluate risk factors associated with MRSA SSTI, they used a multivariate logistic regression approach with two different statistical models. They included a total of 1,134 patients. Positive cultures were observed in 498 patients; of these, 259 (52%) had Staphylococcus aureus positive cultures. To evaluate risk factors associated with MRSA SSTI, they used a multivariate logistic regression approach with two different statistical models. Findings suggest that in Colombia, community-acquired SSTIs are commonly caused by MRSA. In the first model, the presence of an abscess, cellulitis, age 18–44 years, and previous outpatient treatment in the previous index visit were identified as independent risk factors for MRSA SSTI; surgical site infection was a protective factor. The second model identified previous outpatient treatment in the previous index visit as the main risk factor. They recommend clinicians to account for MRSA when designing the initial empirical treatment for purulent SSTI in Colombia.