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Risk factors and nomogram for diabetes mellitus in idiopathic chronic pancreatitis

Journal of Gastroenterology and Hepatology Nov 01, 2019

Liu Y, Wang D, Guo HL, et al. - Researchers sought risk factors for diabetes mellitus (DM) in idiopathic chronic pancreatitis (ICP). Further, they aimed at developing a nomogram for the same to help early diagnosis. Among 1,633 enrolled patients with ICP, DM developed in 26.3% (430/1633) of patients during the median follow-up duration of 9.8 years. Risk factors for DM development were adult at the onset of ICP, biliary stricture at/before diagnosis of CP, steatorrhea at/before diagnosis of CP, and complex pathologic changes in main pancreatic duct. In the training and validation cohorts, good concordance indexes were achieved with the nomogram with well-fitted calibration curves.
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