Keita Miki, et al. - Given the significance of identifying risk factors and localization of silent cerebral infarction (SCI), especially in younger patients with atrial fibrillation (AF), researchers analyzed 286 consecutive neurologically asymptomatic patients who underwent AF ablation from January 2014 to July 2017 to address these issues. Two radiologists independently classified SCIs as: cardiogenic SCI in 19 patients, lacunar SCI in 13, undetermined causes in 6, and no SCI in 248 (controls). Findings suggested that SCI localized in the cerebral cortex and cerebellum is frequently reported among AF patients, for which cardiogenic mechanisms may be mainly involved. In addition, the investigators noted the utility of CHA₂DS₂-VASc score for screening SCI, and left atrial abnormality as the specific marker for cardiogenic SCI, providing useful information for risk stratification of SCI.