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Risk factors and diagnostic markers of bacteremia in Stevens-Johnson syndrome and toxic epidermal necrolysis: A cohort study of 176 patients

Journal of the American Academy of Dermatology Jul 20, 2019

Koh HK, et al. - Because sepsis is the leading cause of death in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), researchers by performing a retrospective cohort study over a 14-year period (2003-2016) identified bacteremic predictive admission risk factors and associated clinical or biochemical markers with positive blood cultures. Participants in the study were 176 patients with SJS (n = 59), SJS-TEN overlap (n = 51), and TEN (n = 66). Risk factors for bacteremia were hemoglobin ≤10 g/dL, cardiovascular disease, and body surface area involvement ≥10% on admission. Hypothermia and elevated procalcitonin are useful markers for bacteremia's timely detection.
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