Orive M, Aguirre U, Gonzalez N, et al. - In this prospective cohort analysis, researchers investigated and sought validation for risk factors contributing to prolonged length of hospital stay (LOS) in patients undergoing resection for colorectal cancer. This study included 1,955 cases from 22 hospitals. Postoperative reintervention, surgical site infection, open surgery, and distant metastasis were identified as the strongest independent predictors of prolonged LOS. Depending on the LOS of the index admission, the patients were clustered into different groups. The likelihood of experiencing adverse outcomes within 30 days following discharge was more in those with prolonged LOS. Modification of some of the strongest independent predictors, such as surgical infections or open surgery, could be done to decrease LOS and, thereby, other adverse consequences.