Tamaki N, et al. - The prediction accuracy for hepatocellular carcinoma (HCC) development by noninvasive markers were compared. Researchers measured magnetic resonance elastography (MRE) and serum fibrosis markers 12 weeks following the end of treatment in a total of 346 chronic hepatitis C infected patients without a history of HCC who achieved sustained virological response (SVR) through direct-acting antivirals. Further, they examined the subsequent HCC development in these patients. HCC developed in 24 patients during a mean observation period of 26.4 ± 7.9 months. As per the multivariate analysis, HCC development could be independently predicted with liver stiffness ≥3.75. MRE vs serum fibrosis markers had higher diagnostic accuracy for predicting HCC development. Patients with high and low risk of HCC development after SVR could be identified via measuring liver stiffness by MRE.