Jepsen P, Tapper EB, Deleuran T, et al. - This study sought to examine risks and outcomes of venous and arterial thrombosis. Nationwide Danish healthcare registries were used to distinguish outpatients with cirrhosis and a gender- and age-matched comparison cohort without cirrhosis from the general population. They calculated absolute risks and hazard ratios of thrombosis, and outcomes were compared after thrombosis. The research enrolled 5,854 individuals with cirrhosis (median MELD score 9, IQR 7–13), and their risk of any of the thrombotic events was 0.8% after 1 year and 6.3% after 10 years. The results demonstrate that individuals with cirrhosis had an increased risk of venous thromboembolism and ischemic stroke, but not acute myocardial infarction. Decompensation increased the risk of myocardial infarction, exclusively among patients with cirrhosis. After thrombosis, mortality was higher in patients with cirrhosis than in other patients. In patients with cirrhosis, these outcomes are relevant for decisions about antithrombotic prophylaxis.