Stachon P, et al. - For patients with aortic valve stenosis at a higher operative risk, transfemoral transcatheter aortic valve replacement (TF-TAVR) is suggested, so researchers conducted subgroup analyses for a number of at-risk populations with adequate patient numbers to obtain TF-TAVR outcomes. On the basis of International Classification of Diseases (ICD) and OPS (Operation and procedure key) codes, the records of 33,789 SAVR or TF-TAVR procedures performed in Germany between 2014 and 2015 were analyzed. In patients with increased operational risk, >80 years old, advanced kidney failure, and highly symptomatic patients, the risk of in-hospital mortality was lower. For patients at increased operative risk, aged >80 years, in NYHA-Class III/IV, and with renal failure, treatment with TF-TAVR was superior.