Masenga SK, et al. - This work was designed aimed to ascertain the prevalence of rifampicin resistance in tuberculosis patients at Livingstone Central Hospital for the year 2015. As per findings, prevalence of rifampicin resistance was 5.9% and there was no statistical significant difference between being male or female. Findings thus suggested the necessity for further in-depth research and appropriate interventions (i.e close follow-up and patient care for drug resistance positive patients).