Maurice-Stam H, et al. - In this investigation, researchers gave a comprehensive overview of the psychosocial developmental trajectory of various diseases during childhood and adolescence. Studies of 18-35-year-old Dutch young adults who had grown up with a chronic illness were included if the Course of Life Questionnaire was used to evaluate psychosocial developmental milestones in three domains: social, autonomy and psychosexual. Seventeen studies involving 1,899 young adults who had grown up with 18 different paediatric diseases were included. In all three questionnaire domains, psychosocial development was delayed. The most affected disease groups were an end-stage renal disease, galactosaemia (males), childhood cancer and orthotopic liver transplants. Chronically ill children and adolescents were at risk of delays in psychosocial development. Health care providers should address this along with the physical elements of illnesses and concentrate on the patient's optimal psychosocial development.