• Profile
Close

Reversal of low donor chimerism following hematopoietic cell transplantation using pentostatin and donor lymphocyte infusion: A prospective phase II multicenter trial

Biology of Blood and Marrow Transplantation Oct 18, 2017

Bar M, et al. - A multicenter prospective Phase II study was planned to examine the safety and efficacy of pentostatin followed by donor lymphocyte infusion (DLI) in patients with low donor T-cell chimerism after allogeneic hematopoietic cell transplantation (HCT). Findings suggested that pentostatin/DLI had acceptable toxicity. It seemed increasing low donor CD3 chimerism after HCT but had no impact on mortality.

  • This study enrolled 36 patients with low donor blood CD3 chimerism.
  • A total of 41 DLIs were offered to 35 patients following a dose of pentostatin, and one patient was administered pentostatin only.
  • In this study, median donor CD3 chimerism prompting the initiation of pentostatin/DLI was 28 (5 to 47)%.
  • In 16 patients (44.4%), responses (defined by increases in donor CD3 chimerism ≥10% maintained to day 56 post-DLI) were observed with a median rise in CD3 donor chimerism to 64 (48 to 100)%.
  • Among the 21 patients who received first treatment within 100 days after transplant, a trend for better responses (57% response rate) was observed compared to the 15 patients who received first treatment more than 100 days after HCT (27% response rate) (p=0.07).
  • At a median of 10 (0 to 83) days after DLI, grade II-IV acute GVHD developed in14 patients (39%).
  • Extensive chronic GVHD developed in ten patients (28%).
  • After DLI, new grade 4 cytopenias developed in 17 patients (47%).
  • Findings revealed no difference in relapse between non-responders and responders.
  • Findings revealed death of 28 patients (78%), these were mostly (n= 21) due to relapse.
  • At a median 60 (range 21 to 132) months after DLI, five of the 16 responders (31%) were alive, all disease-free.
  • At median of 47 (range 16 to 100) months after DLI, 6 of the 20 non-responders (30%) were alive, 3 in complete remission.

Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay