Blok F, et al. - Researchers examined BRCA1/2 carriers presenting for risk-reducing salpingo-oophorectomy (RRSO), to determine the prevalence of high grade serous carcinoma and serous tubal intraepithelial carcinoma (STIC) in these subjects, including the follow-up period. Overall 527 cases were studied, of those BRCA1, BRCA2, and both mutations were present in 68%, 31.6%, and 0.4% cases, respectively. Findings revealed a more common prevalence of high grade serous carcinoma in BRCA1/2 carriers who presented for RRSO following the recommended age, and more often it had a tubal origin. The development of peritoneal serous carcinoma was reported >7 years later in two BRCA1 carriers with isolated STIC at RRSO. Considering longer follow up of patients with STIC at RRSO was recommended.