Riggins N, et al. - In this small pilot study, researchers appraised the prophylactic effectiveness of an intravenous (IV) valproate sodium, an anti-epileptic and mood stabilizer, for migraine in patients with chronic migraine refractory to multiple preventive medications. For a 4-day course of IV valproate sodium, 14 adult patients with chronic migraine were admitted and were administered 250 mg of valproate sodium over a standard infusion time of 60 minutes every 8 hours. This small pilot study had promising outcomes for patient headache improvement. Further, patients with chronic migraine who were resistant to oral medications showed good tolerability towards this repetitive dosing valproate sodium protocol.