Faig J, et al. - Experts proposed an outpatient high-dose cisplatin protocol aimed at preventing nephrotoxicity and evaluated the results of its utilization in patients with squamous cell carcinoma of the head and neck (SCCHN) treated with concurrent radiotherapy. During treatment, the incidence of acute kidney injury (AKI) was 34.2%. Lower baseline weight and creatinine, higher baseline creatinine clearance, smoking, female sex, African American race, hypertension, and increased hydration and magnesium replacement requirements were the predictors associated with AKI and chronic kidney disease. Data suggested that early and late nephrotoxicity was encountered by the experts. Essentially, nephrotoxicity was not the main dose-limiting toxicity. Importance of close monitoring and additional replacement of water and electrolytes as needed, was emphasized in the findings.