Cascavilla ML, et al. - The goal of this paper was to inquire regarding the preganglionic retinal function with the aid of the multifocal electroretinogram (mfERG), in patients affected by dominant optic atrophy (DOA) stratified by OPA1 gene mutation. This study reported the occurrence of the preganglionic retinal impairment in DOA, with a clear genotype to retinal dysfunction association. Missense mutations appeared to be characterized by a far more severe functional impairment.