Hsu CC, Hsu I, Hsu L, et al. - Researchers aimed at examining the effectiveness of whole dimension subcortical ovarian administration of platelet-rich plasma with gonadotropin, in proximity to most ovarian follicles, in restoring ovarian functions in women during early menopause. Extended subcortical area of bilateral ovaries was injected with platelet-rich plasma, prepared from 40 mL of autologous peripheral blood, using the buffy coat method, along with recombinant follicle-stimulating hormone (rFSH) (Gonal-F 300IU) under laparoscopic guidance. They enrolled 12 early menopausal women with a mean age of 44.42 ± 2.84. After treatment, resumption of menstrual period was recorded in 11 women in 37.1 ± 23.5 days. Overall there was restoration of ovarian functions, at least temporarily, in correlation with whole dimension subcortical ovarian administration of platelet-rich plasma with gonadotropin; hence this could enhance the probability of pregnancy using autologous oocytes in women with early menopause.