Tommerdahl KL, Bjornstad P, Kendrick J, et al. - This study was attempted to evaluate the impact of metformin on markers of inflammation and diabetic kidney disease (DKD) in youth with type 1 diabetes (T1D). Researchers designed a double‐blind, randomized, placebo‐controlled trial including a total of 48 youth aged 12‐21 years with T1D, included baseline and follow‐up assessments of serum creatinine and cystatin C to calculate glomerular filtration rate (eGFR), AST, ALT, highly sensitive c‐reactive protein, white blood count, platelets, adiponectin, leptin, and urine albumin: creatinine ratio (UACR). There were no variations with cystatin C, UACR, or systemic inflammatory markers, whereas the estimated glomerular filtration rate assessed by serum creatinine elevated significantly following metformin. Future evaluations with directly measured GFR in response to metformin in T1D are needed.