Cederberg KLJ, et al. - In people with multiple sclerosis (MS), researchers studied the connections among restless legs syndrome (RLS), symptoms, and health-related quality of life (HRQOL). Two hundred seventy-five MS participants completed the Cambridge-Hopkins Restless Legs Syndrome Questionnaire, the International Restless Legs Syndrome Study Group Scale, the Multiple Sclerosis Impact Scale, the Pittsburgh Sleep Quality Index, the Fatigue Severity Scale, the Hospital Anxiety and Depression Scale and the Patient Determined Disease Steps. Findings revealed that there were 74 (26.9%) people with MS who had RLS (MS + RLS). RLS severity was linked with physical and psychological HRQOL, sleep quality, perceived fatigue, depression and anxiety in the MS + RLS group. When accounting for fatigue, depression and/or anxiety, the links between RLS severity and the domains of HRQOL were reduced. Worse severity of RLS was correlated with decreased HRQOL, due to fatigue, depression, and anxiety.