Campbell JP, et al. - This study was planned to determine how monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma plasma cell clones responded to anti-multiple myeloma therapy in patients newly diagnosed with biclonal gammopathy multiple myeloma. As per finding, in these patients, anti-multiple myeloma therapies exert a greater depth of response against multiple myeloma plasma cell clones than MGUS plasma cell clones. Despite a complete response exhibited by some MGUS clones, many did not respond, suggesting the presence of the underlying features that render multiple myeloma plasma cells susceptible to therapy in only some MGUS plasma cell clones.