Ghosh A, Yadav R, Gamanagatti S, et al. - Researchers examined if respiratory triggered unidirectional single-shot echo-planar imaging (u-SSEPI) is a time-saving measure in diffusion imaging of the upper abdomen. In particular, the apparent diffusion coefficient (ADC) values obtained from unidirectional DWI(u-SSEPI) and routine DWI (4t-SSEPI) were compared. Furthermore, they examined the diagnostic accuracies of unidirectional vs routine DWI sequences in the identification of focal liver lesions in the setting of chronic liver disease (CLD). A total of 48 patients with CLD who underwent-DCE-MRI on a 1.5 T scanner for hepatocellular carcinoma (HCC) workup were assessed in this prospective, IRB approved study. Along with 4t-SSEPI, they acquired u-SSEPI with the diffusion sensitising gradient being applied in only one direction; keeping the rest of the parameters the same as 4t-SSEPI. Using DCE-MRI, follow-up imaging and patient clinical details, establishment of a composite gold standard was done. They identified 88 lesions employing the composite gold standard. Three times faster image acquisition was observed in correlation with u-SSEPI. Overall findings revealed no significant differences in the diagnostic accuracies of unidirectional and routine DWI in the diagnosis of HCC.