Korten I, Oestreich MA, Frey U, et al. - Given infants with cystic fibrosis (CF) can encounter lung disease within the first year of life but the frequency as well as severity of respiratory symptoms in infancy are unknown, thus to explore this topic, researchers herein examined respiratory symptoms in 50 infants experiencing CF and 50 healthy matched controls from two prospective birth cohort studies. They assessed 4,552 data points (2217 in CF). It was found that infants with CF did not have more frequent respiratory symptoms (either mild or severe). In infants with CF, higher lung clearance index and higher respiratory rate were not related to respiratory symptoms. Findings revealed that respiratory symptoms did not differ between healthy and CF infants. According to results, clinical presentation alone may not capture early CF lung disease.