Gutierrez AD, Flores CA, Naik S, et al. - In a Mexican-American cohort, an unexpected reduction in resistin was noted as insulin resistance (IR) increased and there is evidence of a resistin-stimulated cytokine pathway in this population.

• Cross sectional study of 953 adults split into three groups: normal glucose tolerance, prediabetes, and diabetes mellitus.

• Unadjusted model (Model 1), model adjusted for cytokines (Model 2), and model further adjusted for demographic and anthropometric variables (Model 3) were applied.

• An increase in HOMA-IR was evident with worsening glucose tolerance.

• Model 3 resistin showed a positive link with IL-1β and IL-8, and an inverse relation to TNF-α, and nonsignificant association with IL-6.

• Decrease in leptin was seen with increased IR post-adjustment for cytokines, demographic and anthropometric variables.

• Adiponectin non-significantly fell as IR rose while demonstrating significant links with gender, BMI, and lipids.